Tumour grows with the help of its environment
Cancer stem cell activity may not merely be an intrinsic characteristic of a subset of cancer cells. It could be regulated by environmental cues.
Prof. dr. Jan Paul Medema of the AMC and colleagues found that high Wnt activity in human colorectal cancer designates a tumour-initiating population that is orchestrated by the microenvironment. The results have been published online in Nature Cell Biology.
