BAC and Octapharma extend collaboration
Under the terms of the license, Octapharma can use BAC’s G-CSF CaptureSelect custom affinity ligand for the purification of recombinant human granulocyte-colony stimulating factor (G-CSF) from human (HEK293F) cell cultures. Existing G-CSF products are marketed as Filgrastim (E.coli derived), and Lenograstim (CHO derived).
This license follows success in an earlier collaboration (the feasibility study program), in which BAC discovered and developed the anti-G-CSF ligand in close collaboration with Octapharma.
This custom-designed affinity chromatography media enables Octapharma to rapidly setup a production process for this recombinant protein as it decreases valuable time needed for down stream process development. More traditional methods used include a range of conventional chromatography steps resulting in a lower recovery of the overall process compared to using affinity chromatography.
G-CSF is a hormone that stimulates bone marrow to produce white blood cells and stem cells, and has therapeutic uses in oncology and haematology. Octapharma will produce G-CSF for use primarily within the field of oncology, for example after chemotherapy and/or bone marrow transplantation.
Source: BAC
