AMC research shows that HIV subverts innate signaling
HIV, the virus that causes aids, uses the immune system to multiply itself. This unexpected discovery by the group of prof. dr. Teunis Geijtenbeek of the Center for Experimental and Molecular Medicine in the AMC was published this week in Nature Immunology.
HIV-1 replication requires proviral production of full-length transcripts. Geijtenbeek and colleagues show that early Tat-independent HIV-1 replication coopts innate receptor signaling by DC-SIGN and TLR8 to promote RNA polymerase II elongation complexes at long terminal repeats.
Source (Dutch): AMC
Please find the full article on the website of Nature Immunology
Source (Dutch): AMC
Please find the full article on the website of Nature Immunology
