SILS III
Controlled Light Exposure Microscopy
Since 1994, Dr E. Manders has worked intensively in the field of
live-cell imaging, observing that cells often die during microscopic
observation due to the toxic effect of illumination light. Years later,
he invented a method to reduce light without compromising image
quality, using illumination photons more effectively. The first
prototypes proved 5 to 10-fold reduction of phototoxicity.
Collaboration with an industrial partner will bring the CLEM technique to the market by the end of 2005. The technology is being improved for a broader field of application (clinical research and pharmacology). CLEM is expected to become a standard technique. .
