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Success stories
Successful efforts in developing novel drugs, preventive tools and diagnostics are increasingly dependent on intensive interactions between medical centres, basic research institutes, spin-off companies and the industry. The following are examples of effective collaborations and illustrate a number of innovative discoveries and successful spin-offs.
Agendia
Molecular diagnostics to improve treatment decisions and allow personalized medicine in cancer.
Agendia focuses on the development of new tools, based on gene expression profiling, to individualize the therapy decisions for cancer patients.
Academic Medical Center (AMC)
DNA isolation method by Boom and Sol
Boom and Sol’s invention provides a tool to isolate specific DNA and RNA molecules of different natures from human body fluids in minute amounts.
The Amsterdam cohort study on HIV and AIDS
AMC’s retrovirology department has been a world leader in AIDS/HIV research since the discovery and has provided many insights into HIV mechanisms and antiviral strategies.
The International Antiviral Therapy Evaluation Center (IATEC)
IATEC is one of the world's leading organizations for clinical research into prevention and treatment of HIV and other viral infections with 52 employees.
The Lipid Research Group
University of Britisch Columbia (UBC), the Academic Medical Center (AMC) and Amsterdam Molecular Therapeutics (AMT), together developed a gene therapy for Lipoprotein Lipase Deficiency.
Netherlands Cancer institute (NKI)
Advances in mass spectrometry
Recent advances in mass spectrometry are accelerating the identification of protein biomarkers for many diseases, including cancer. Clinical proteomics is the characterization of disease-related proteins in biological matrices of patients.
DNA encoding of a tumour antigen
A Good Manufacturing Practice (GMP) facility for the production of clinical-grade naked DNA vaccines was built in the NKI-AVL/Slotervaart Hospital to support early clinical trials.
RNA interference in mammalian cells
RNA interference (RNAi) is a powerful tool to perform loss-of-function genetic screens in mammalian cells. We use large collections of retroviral RNAi vectors to identify novel drug targets in disease.
Swammerdam Institute of Life Sciences (SILS)
Gallium brings Virtual Reality technology to the market
Business Strategist Gallium Europe (Gallium) and the Center of Mathematics and Information Technology (CWI) joined forces to bring Virtual Reality technology to the market.
Treatment of suppressed neurogenesis
Cell genesis in the brain is suppressed by chronic stress. The good news is that it can be treated!
Controlled Light Exposure Microscopy
Controlled Light Exposure Microscopy (CLEM) is a fundamentally new approach to imaging that strongly reduces undesired phototoxicity in microscopy of living cells, without compromising image quality.
Epigenetic Code Reader
SILS developed the ‘Epigenetic Code Reader’ (ECR). This system can analyze the regulatory layer on top of the DNA sequence (histone code).